人参皂苷 S-RH2_化工百科

中文名	人参皂甙 Rh2
英文名	Ginsenoside Rh2
别名	人参皂荚RH2 人参皂甙 Rh2 人参皂苷 Rh2 人参皂苷-RH2 人参皂苷RH2(R) 人参皂苷 S-RH2 (R型)人参皂苷RH2 人参皂苷RH2(标准品) (S型)人参皂苷RH2(标准品)
英文别名	GINSENOSIDE RH2 Ginsenoside Rh2 R-form-Ginsenoside Rh2 Ginsenoside Rh2, 20(S)- dihydroxydammar-24-en-3-yl β-D-Glucopyranoside, (3β,12β)-12,20- (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside b-D-Glucopyranoside, (3b,12b)-12,20-dihydroxydaMMar-24-en-3-yl (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside (3beta,12beta)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside
CAS	78214-33-2
化学式	C36H62O8
分子量	622.88
InChI	InChI=1/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1
InChIKey	CKUVNOCSBYYHIS-IRFFNABBSA-N
密度	1.19±0.1 g/cm3(Predicted)
熔点	139-144 °C
沸点	726.4±60.0 °C(Predicted)
比旋光度	+23°（c0.65，methanol）
闪点	393.1°C
蒸汽压	2.31E-24mmHg at 25°C
溶解度	DMSO : ≥ 100 mg/mL (160.55 mM)
折射率	1.571
酸度系数	12.91±0.70(Predicted)
存储条件	Inert atmosphere,2-8°C
敏感性	Easily absorbing moisture
外观	整洁
物化性质	白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。
MDL号	MFCD00800712
体外研究	Ginsenoside Rh2 induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner and is therefore a promising candidate for anti-tumor drug development. Ginsenoside Rh2 triggers p53-dependent Fas expression and consequent activation of caspase-8 and p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.The cytotoxic activity of Ginsenoside Rh2 in the human tumor cell lines HeLa, SK-HEP-1, SW480, and PC-3 is assessed by MTT. The cell viability of HeLa cells is remarkably inhibited by Ginsenoside Rh2, with an IC 50 value of 2.52 μg/mL, whereas SK-HEP-1 and SW480 cells are less sensitive to Ginsenoside Rh2, with IC 50 values of 3.15 μg/mL and 4.06 μg/mL, respectively. PC-3 cells are the least vulnerable to Ginsenoside Rh2, with an IC 50 value of 7.85 μg/mL, 3-fold higher than HeLa cells.
体内研究	A total of 15 days following B16-F10 cell injection, tumor sizes from the 3 tumor bearing groups are measured. The tumor sizes in the G-L group and G-H group (G-L and G-H refer to a low or high dose of ginsenoside Rh2 injection) are reduced compared with the tumor group (P<0.05). The survival analysis reveals that the Ginsenoside Rh2 treated groups survive longer than the untreated tumor group and the effect is dose-dependent (P<0.05).
危险品标志	Xn - 有害物品
风险术语	22 - 吞食有害。
安全术语	24/25 - 避免与皮肤和眼睛接触。
WGK Germany	3
RTECS	LZ5776539
海关编号	29389090
参考资料展开查看	1. 陈钰泉刘玉婷邱杰等. 不同比色法测定植物源总三萜皂苷含量的对比[J]. 黑龙江农业科学 2018 000(003):108-112. 2. 马晓伟于蒙蒙晋兴华等. 人参次苷H滴丸原料药中皂苷含量测定及细胞膜色谱技术对效应成分筛选[J]. 中草药 2018 v.49;No.622(11):62-67. 3. 聂柳彭罕鸣.人参皂苷Rh2对人急性T淋巴细胞白血病Jurkat细胞诱导凋亡的作用及其机制[J].中国实验血液学杂志 2019 27(04):1111-1117. 4. 张彩华李骢李华军等. 人参皂苷Rh2对肺癌A549细胞miR-16和Bcl-2表达与生长的影响研究[J]. 中国微生态学杂志 2015 27(009):1027-1030. 5. 崔勇李世明金燕等. 人参皂苷Rh2通过VEGF/MMP-9信号通路抑制哮喘小鼠气道重塑的实验研究[J]. 中华中医药学刊 2017(08):14-17. 6. 张蕾, 郝婧玮, 景云荣,等. 紫苏叶对高尿酸血症模型小鼠的影响. 7. 苗瑞, 吴冬雪, 王秋颖,等. 基于多壁碳纳米管的人参皂苷快速分离[J]. 高等学校化学学报, 2018. 8. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 9. Xu, Xiang, et al. "Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway." Journal of Ginseng Research 44.5 (2020): 704-716.https://doi.org/10.1016/j.jgr.2019.06.002 10. Wang, Zhihua, et al. "Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs." Analytical and bioanalytical chemistry 411 11. Zhang, Hong-Mei, et al. "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https://doi.org/10.1016/j.jpba.2012.01.010 12. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 13. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 14. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 15. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 16. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 17. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 18. [IF=6.06] Xiang Xu et al."Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway."J Ginseng Res. 2021 Apr;: 19. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;: 20. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 21. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 22. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 23. [IF=4.029] Xiang Xu et al."Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway."J Ginseng Res. 2020 Sep;44:704 24. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 25. [IF=2.547] Zhongyi Cong et al."Ginsenoside Rh3 Inhibits Proliferation and Induces Apoptosis of Colorectal Cancer Cells."Pharmacology. 2020;105(5-6):329-338 26. [IF=6.543] Liang Yuan et al."Identification of 20(S)-Ginsenoside Rh2 as a Potential EGFR Tyrosine Kinase Inhibitor."Oxid Med Cell Longev. 2022;2022:6119737

人参皂苷 S-RH2 - 简介

人参皂苷Rh2是一种从人参中提取的天然化合物。它是一种人参皂苷的成分，是一种三萜类化合物。

人参皂苷Rh2具有多种生理活性，包括抗疲劳、抗氧化、抗肿瘤、调节免疫功能和促进血液循环等。它还具有抗炎、抗病毒和抗衰老的作用。

人参皂苷Rh2可以通过人参的水提取物进行制备。一种常见的方法是将人参干燥、粉碎，然后用水浸泡进行提取。接着，通过过滤、浓缩和结晶等步骤来纯化Rh2。

在使用人参皂苷Rh2时，应注意以下安全信息：
遵循剂量指示，不要超过推荐剂量。
孕妇、哺乳期妇女和儿童应避免使用。
对人参皂苷Rh2过敏的人应禁止使用。
长期使用可能会导致一些副作用，如头晕、口干、失眠等，如出现不适症状应停止使用并咨询医生。

最后更新：2024-04-09 15:16:52

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产品名: 人参皂甙 Rh2 去供应商网站查看询盘
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